|
KMID : 1123920020160030584
|
|
Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 3 p.584 ~ p.587
|
|
|
Effect of Benincasae Semen on Cultured Mouse Cerebral Neurons Damaged by Streptozotocin
|
|
Lee Whan-Bong
Lee Kang-Chang
Lee Ki-Nam
Hong Kee-Yeon
Suk Seung-Whan
Cho Chung-Gu
Jung Seon-Kwan
Hur Jung-Mu
Lee Sang-Bork
Seo Eun-A
Song Ho-Jun
Lee Young-Chan
Park Seung-Taeck
|
|
|
Abstract
|
|
|
|
It has been suggested that oxidative stress may play an important role in the pathogenesis of diabetic complications. The purpose of this study was to examine the oxidative stress of streptozotocin(STZ) in the cultured mouse cerebral neurons and the preventing effect of vitamin E and and Benincasae Semen(BS) on STZ-induced neurotoxicity. Cytotoxic effect of STZ and neuroprotective effect of antioxidant and BS were performed by MTT assay. 30 μM STZ decreased cell viability in dose-and time-dependent mannner, and vitamin E and BS diminished STZ-induced neurotoxicity in these cultures. From above the results, STZ has toxic effect. and antioxidants, vitamin E or herb extract of BS is very effective against STZ-induced neurotoxicity in cultured cerebral neurons of neonatal mouse.
|
|
|
KEYWORD
|
|
|
Cultured mouse cerebral neuron, Benincasae Semen, Antioxidant
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|